Progesterone Receptor
NR3C3
Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.
Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.
In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).
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Progesterone Receptor Inhibitors
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Progesterone Receptor Agonists
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Progesterone Receptor Antagonists
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Progesterone Receptor Activators
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Progesterone Receptor Modulators
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Progesterone Receptor Ligands
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Progesterone Receptor Proteins
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Progesterone Receptor Related Products (161)
Related Products (161)
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Recombinant Proteins (1)
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Antibodies (2)
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Mifepristone methochloride
0 ImagesCat. No.: HY-167932CAS No.: 109345-60-0Synonyms: RU486 methochloride; RU 38486 methochlorideMifepristone (RU486) methochloride is a glucocorticoid antagonist that blocks peripheral glucocorticoid and progesterone receptors. Mifepristone methochloride has been shown to have minimal effects on intraocular pressure in treated rabbits. Mifepristone methochloride was developed as a water-soluble formulation to enhance ocular penetration of the drug.
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Dienogest-13C,15N,d4
0 ImagesCat. No.: HY-B0084S4Synonyms: STS 557-13C,15N,d4Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the 13C, 15N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.
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EIDD-036
0 ImagesCat. No.: HY-17649CAS No.: 211302-60-2EIDD-036, is the blood-brain barrier penetrant C-20 oxime of Progesterone (HY-N0437), that binds progesterone receptor (PR) with an IC50 of 171 nM. EIDD-036 is the active metabolite of EIDD-1723 (HY-125547). EIDD-036 exhibits promising challenges for rapid administration in acute trauma. EIDD-036 can be used for the study of traumatic brain injury (TBI).
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Dydrogesterone (Standard)
0 ImagesDydrogesterone (Standard) is the analytical standard of Dydrogesterone. This product is intended for research and analytical applications. Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.
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Clogestone acetate
0 ImagesClogestone acetate (AY-11440) is an orally active progesterone receptor agonist. Clogestone acetate reduces adrenal and ovarian weight, as well as serum and adrenocortical ketone levels in rats.
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Fenprostalene
0 ImagesCat. No.: HY-126762CAS No.: 69381-94-8Fenprostalene is an analog of Dinoprost (PGF2α) (HY-12956) that is used in veterinary medicine to induce corpus luteum regression and blood Progesterone (HY-N0437) levels reduction in dogs. Fenprostalene is potent in ameliorating pyometra and inducing abortion.
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Drospirenone-d4-1
0 ImagesCat. No.: HY-B0111S1Synonyms: Dihydrospirorenone-d4-1Drospirenone-d4-1 is deuterium labeled Drospirenone.
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Melengestrol acetate-d6
0 ImagesCat. No.: HY-111614SMelengestrol acetate-d6 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
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JNJ-1250132
0 ImagesCat. No.: HY-123163CAS No.: 240805-96-3Synonyms: RWJ-66826; RTI-6617-003JNJ-1250132 (RWJ-66826) is an orally active and potent steroidal progesterone receptor (PR) antagonist, with an IC50 of 1.3 nM. JNJ-1250132 inhibits binding of the receptor to DNA in vitro. JNJ-1250132 is a potent competitive inhibitor of binding to the human glucocorticoid receptor (GR) (IC50=0.50 nM) and the rat androgen receptor (AR) (IC50=5.6 nM), and was a weak inhibitor of binding to human Estrogen receptor (ER) (IC50 >3000 nM).
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Levonorgestrel-d8
0 ImagesCat. No.: HY-B0257SSynonyms: D-Norgestrel-d8Levonorgestrel-d8 is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives. Levonorgestrel-d8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Ulipristal acetate-d6
0 ImagesCat. No.: HY-16508SCAS No.: 1621894-64-1Synonyms: CDB-2914-d6Ulipristal acetate-d6 is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma.
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Hydroxyprogesterone caproate-d8
0 ImagesCat. No.: HY-B0742S1Synonyms: 17α-Hydroxyprogesterone hexanoate-d8; 17α-Hydroxyprogesterone caproate-d8Hydroxyprogesterone caproate-d8 (17α-Hydroxyprogesterone hexanoate-d8) is the deuterium labeled Hydroxyprogesterone caproate (HY-B0742). Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth.
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Trimegestone
0 ImagesCat. No.: HY-106827CAS No.: 74513-62-5Synonyms: RU 27987Trimegestone (RU 27987) is an orally active, selective progestogen and PR ligand, with an IC50 of 7.6 nM for hPR, 4.4 nM for rabbit PR, and 3.3 nM for rat PR. Trimegestone induces Alkaline phosphatase activity. Trimegestone exhibits antiandrogenic activity (IC50 = 303 nM). Trimegestone can be used in research related to menopausal symptoms and osteoporosis.
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Medrogestone
0 ImagesMedrogestone is an orally active Progestin. Medrogestone shows a marked local progestational effect. Medrogestone maintains pregnancy in ovariectomized rats. Medrogestone inhibits ovulation. Medrogestone prevents pregnancy. Medrogestone produces a significant reduction in the severity of benign prostatic hypertrophy.
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EIDD-1723
0 ImagesCat. No.: HY-125547CAS No.: 1659302-89-2EIDD-1723 is a Progesterone (HY-N0437) analogues, that binds progesterone receptor (PR) with an IC50 of 2.25 μM. EIDD-1723 is the prodrug of EIDD-036 (HY-17649). EIDD-1723 may exert its neuroprotective effects not solely through progesterone receptor (PR)-dependent pathways but also via non-genomic mechanisms, such as modulation of inflammatory responses and oxidative stress. EIDD-1723 can be used for the study of traumatic brain injury (TBI).
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CPAG-1
0 ImagesCat. No.: HY-186011CAS No.: 2094991-62-3CPAG-1 is a small-molecule activator of progesterone receptor membrane component 2 (PGRMC2). CPAG-1 can enhance mitochondrial heme delivery to the nucleus mediated by PGRMC2 and activate genes related to heat production in brown adipose tissue (BAT), such as Ucp1 and Pgc-1α, and reduce lipid accumulation in BAT. CPAG-1 reduce fasting blood sugar and insulin levels, and improve glucose tolerance and insulin sensitivity. CPAG-1 can be used for research of type 2 diabetes.
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Onapristone
0 ImagesCat. No.: HY-106389CAS No.: 96346-61-1Synonyms: ZK 98299Onapristone is a progesterone receptor antagonist, with Kds of 11.6 nM and 11.90 nM for human endometrium and myometrium progesterone receptor in saturation analysis. Onapristone has antitumor activity.
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Norethindrone-d7
0 ImagesCat. No.: HY-W746582Synonyms: Norethisterone-d7Norethindrone-d7 (Norethisterone-d7) is the deuterium labeled Norethindrone (HY-B0554). Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
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Nomegestrol
0 ImagesCat. No.: HY-105634CAS No.: 58691-88-6Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
